| Date | Opponent | Time | Location |
| Sept. 12 | Trinity Loss, 22-21 Record: 0-1 (0-0 ASC) | 6 p.m. | Matador Stadium - Seguin, Texas |
| Sept. 19 | Mary Hardin-Baylor* Loss, 59-7 Record: 0-2 (0-1 ASC) | 6 p.m. | Matador Stadium - Seguin, Texas |
| Sept. 26 | at East Texas Baptist* Loss, 32-21 Record: 0-3 (0-2 ASC) | 7 p.m. | Ornelas Field (ETBU) - Marshall, Texas |
| Oct. 3 | Howard Payne* Loss, 45-23 Record: 0-4 (0-3 ASC) | 2 p.m. | Matador Stadium - Seguin, Texas |
| Oct. 10 | at Sul Ross State* Loss, 35-7 Record: 0-5 (0-4 ASC) | 1 p.m. | Jackson Field (SRSU) - Alpine, Texas |
| Oct. 17 | at Incarnate Word Loss, 53-18 Record: 0-6 (0-4 ASC) | 2 p.m. | Benson Stadium (UIW) - San Antonio, Texas |
| Oct. 24 | McMurry* Loss, 36-23 Record: 0-7 (0-5 ASC) | 2 p.m. | Matador Stadium - Seguin, Texas |
| Oct. 31 | at Hardin-Simmons* Loss, 38-22 Record: 0-8 (0-6 ASC) | 2 p.m. | Shelton Stadium (HSU) - Abilene, Texas |
| Nov. 7 | Louisiana College* Loss, 42-3 Record: 0-9 (0-7 ASC) | 2 p.m. | Matador Stadium - Seguin, Texas |
| Nov. 14 | at Mississippi College* Loss, 38-24 Record: 0-10 (0-8 ASC) | 1 p.m. | Robinson-Hale Stadium (MC) - Clinton, Miss. |